16-year-old teen devises way to treat deadly breast cancer .

A 16-year-old boy from Epsom, Surrey, believes he may have the answer to treat deadly breast cancer. Krtin Nithiyandam thinks he has devised a way to turn the most deadly form of triple negative breast cancer into a kind which responds to drugs. 7,500 women each year are diagnosed with triple negative breast cancer, a type of disease which does not respond to today's most effective drugs. Many breast cancers are driven by oestrogen, progesterone or growth chemicals so drugs that can block those fuels, such as tamoxifen, make effective treatments. However triple negative breast cancer does not have receptors and it can only be treated with a gruelling combination of surgery, radiation and chemotherapy which lowers the chance of survival. Scientists have known for some time that some women with triple negative cancer respond very well to treatment while others quickly decline. The problem lies in whether the cancer cells are ‘differentiated’ or not. Differentiated means they look more like healthy cells and they tend to grow and multiply quite slowly, and are less aggressive. However when cancer cells are ‘undifferentiated’ they get stuck in a dangerous primitive form, never turning into recognizable breast tissue, and spreading quickly, leading to high grade tumors. Krtin believes he has found a way to coax these more deadly cells into their differentiated form by blocking a protein called ID4. Most cancers have receptors on their surface which bind to drugs like Tamoxifen but triple negative don’t have receptors so the drugs don’t work.“The prognosis for women with undifferentiated cancer isn’t very good so the goal is to turn the cancer back to a state where it can be treated.“The ID4 protein actually stops undifferentiated stem cell cancers from differentiating so you have to block ID4 to allow the cancer to differentiate. He has also discovered that upping the activity of a tumour suppressor gene called PTEN allows chemotherapy to work more effectively, so the dual treatment could prove far more effective than traditional drugs. The therapy idea, which saw him shortlisted for the final of The Big Bang Fair competition, would most likely be delivered in a nanoparticle containing RNA – the messenger molecule which carries instructions from the DNA. The RNA nanoparticle would be encoded to silence or boost gene activity. continue