UK scientists say they have reached a milestone in the fight against malaria by creating a genetically modified mosquito that is infertile.The plan is to wipe out the insects that spread malaria to people via bites, Nature Biotechnology reports.
Two copies of the mutant gene render the malaria-carrying female insect completely barren.
But one copy is enough for a mosquito mum or dad to pass it on to offspring. This should perpetually spread the infertility gene throughout the population so the species dwindles or dies out.
However, the Imperial College London team say more safety tests are needed, meaning it will be a decade before the mutant mosquitoes can be released into the wild. Cheating nature; The mutant mosquito can still carry and transmit malaria to people via bites. But their genetic make-up means they should breed with and replace other malaria-carrying mosquitoes. Any offspring with one copy of the gene would carry on passing the trait to future generations, while any female offspring that inherits both copies would be unable to reproduce. In this way, the host of the malaria parasite should eventually become extinct. In the Imperial team's experiments with Anopheles gambiae - a breed of mosquito that is rife in sub-Saharan Africa where the bulk of human malaria deaths currently occur - the mutant mosquitoes were kept with wild-type ones so they could mate. The gene for infertility was transmitted to more than 90% of both male and female mosquitoes' offspring across five generations, thanks to technology called gene drive, say the researchers Dr Tony Nolan and Prof Andrea Crisanti.
read more ;http://www.bbc.com/news/health-35024794
UK scientists say they have reached a milestone in the fight against malaria by creating a genetically modified mosquito that is infertile.The plan is to wipe out the insects that spread malaria to people via bites, Nature Biotechnology reports.
Two copies of the mutant gene render the malaria-carrying female insect completely barren.
But one copy is enough for a mosquito mum or dad to pass it on to offspring. This should perpetually spread the infertility gene throughout the population so the species dwindles or dies out.
However, the Imperial College London team say more safety tests are needed, meaning it will be a decade before the mutant mosquitoes can be released into the wild. Cheating nature; The mutant mosquito can still carry and transmit malaria to people via bites. But their genetic make-up means they should breed with and replace other malaria-carrying mosquitoes. Any offspring with one copy of the gene would carry on passing the trait to future generations, while any female offspring that inherits both copies would be unable to reproduce. In this way, the host of the malaria parasite should eventually become extinct. In the Imperial team's experiments with Anopheles gambiae - a breed of mosquito that is rife in sub-Saharan Africa where the bulk of human malaria deaths currently occur - the mutant mosquitoes were kept with wild-type ones so they could mate. The gene for infertility was transmitted to more than 90% of both male and female mosquitoes' offspring across five generations, thanks to technology called gene drive, say the researchers Dr Tony Nolan and Prof Andrea Crisanti.
read more ;http://www.bbc.com/news/health-35024794
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