RESEARCH: New skin test detects prion infection before symptoms appear.

RESEARCH: New skin test detects prion infection before symptoms appear. Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease (CJD) in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected as they destroy brain tissue, causing memory loss, mobility issues, and ultimately death. Preclinical detection of prions has proven difficult, but new research suggests skin samples hold early signs of prion disease that precede neurologic symptoms. Currently, a definitive diagnosis of Creutzfeldt-Jakob disease is dependent on the examination of diseased brain tissue obtained at biopsy or autopsy. It has been impossible to detect at the early preclinical stage," said Wenquan Zou, MD, PhD, associate professor of pathology at Case Western Reserve University School of Medicine. In a ground-breaking study published in Nature Communications, Zou and an international team of researchers successfully used two methods to detect prions in skin samples collected from inoculated rodents. The study provides the first proof-of-concept evidence that readily accessible skin samples could be used to detect prion disease early -- before clinical symptoms appear. In the new study, Zou and colleagues successfully detected prions in rodent skin samples as early as two weeks post-infection. They also detected prions in the skin of uninoculated rodents that were housed alongside inoculated cage mates, demonstrating that prion transmission can occur between cohabiting rodents.

RESEARCH: Eyes of Creutzfeldt-Jakob disease( CJD) patients show evidence of prions.

RESEARCH: Eyes of Creutzfeldt-Jakob disease patients show evidence of prions. Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, fatal brain disorder. It affects about one person in every one million per year worldwide; in the United States there are about 350 cases per year. CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs) or prion diseases. A prion—derived from “protein” and “infectious”—causes CJD in people and TSEs in animals. Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges when examined under a microscope. CJD is the most common of the known human TSEs. CJD usually appears in later life and runs a rapid course. The typical onset of symptoms occurs at about age 60, and about 70 percent of individuals die within one year. In the early stages of the disease, people may have failing memory, behavioral changes, lack of coordination, and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur. There are three major categories of CJD. 1)In sporadic (sCJD), the disease appears even though the person has no known risk factors for the disease. This is by far the most common type of CJD and accounts for at least 85 percent of cases. 2)In hereditary CJD, the person may have a family history of the disease and test positive for a genetic mutation associated with CJD. About 10 to 15 percent of cases of CJD in the United States are hereditary. 3) in acquired CJD, the disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. There is no evidence that CJD is contagious through casual contact with someone who has CJD. Since CJD was first described in 1920, fewer than one percent of cases have been acquired CJD. A type of CJD called variant CJD (or vCJD) can be acquired by eating meat from cattle affected by a disease similar to CJD called bovine spongiform encephalopathy (BSE) or, commonly, “mad cow” disease. A new study, researchers at University of California San Diego School of Medicine with colleagues at the National Institutes of Health and UC San Francisco, report finding tell-tale evidence of the condition's infectious agent in the eyes of deceased sCJD patients, making the eye a potential source for both early CJD detection and prevention of disease transmission. In the November 20 issue of the journal mBio, co-corresponding author Christina J. Sigurdson, DVM, PhD, professor of pathology at UC San Diego and UC Davis, and colleagues discovered high levels of prions in the eyes of 11 deceased patients, all with confirmed sCJD. Almost half of sCJD patients develop visual disturbances, and its a known fact that the disease can be unknowingly transmitted through corneal graft transplantation.

DISEASE TRANSMISSION AND BIOSECURITY PROTOCOLS.

BIOSECURITY.  Following simple but specific protocols everyday to positively influence animal health, food safety and public health.

 What are the basic protocols in biosecurity? READ

 Biosecurity basically entails, prevention of pathogens from entering premises to ensure there is no disease incidence, and curtail spread of diseases in cases of outbreaks.

  Pathogens are disease causing microorganisms that usually have devastating effect on animals, resulting in decreased production and death in severe cases.  Pathogens can be bacteria, viruses, fungi and prion.

.  The animal kingdom is riddled with several pathogens that wreck havoc on these animals irrespective of specie.  These pathogens are also of importance to man, especially when these cause zoonotic diseases.

 Zoonotic diseases are spread from animals to man, and sometimes there is a reverse zoonoses where man actually spreads the disease to their animals.

  Route of transmission.  The basic routes are:  Direct contact.  Aerosol.  Oral.  Formites.  Vector borne  Zoonoses.  Reproduction.  Environmental contamination.

  Mode of transmission.  Direct contact ;disease spread by contact with open wounds, mucous membrane of an infected animal or its secretions/tissue fluids.

Disease can also spread through contact with reproductive fluid(blood, urine and saliva) during breeding, or from mother to offspring.

  Aerosol; droplets containing the pathogenic agent travel in air and are inhaled as respiratory droplets by animals

 Oral; ingestion of the pathogenic agent from contaminated feed ,chewing/licking contaminated objects in environment and water.

 Formites; spread of the pathogen through contact with inanimate objects contaminated by infected animals.

Man can act as formites by transferring these pathogens in through soiled boots, gloves or tools.

AGRIBUSINESS: GlobalG.A.P. as a Way to Safer Food and Safer Food as a Way to a Better Business.

AGRIBUSINESS: GlobalG.A.P. as a Way to Safer Food and Safer Food as a Way to a Better Business.

An international study conducted by Unilever reveals that more than a third of consumers (33%) are now choosing to buy from companies they believe are producing in accordance with ecological principles, and the majority of consumers nowadays expect that products they buy fulfill high social, ecological and ethical standards (source: Unilever). 

 When buying, consumers are wondering: 'Is this product good for my family and me? Is this produced in a healthy way? Although the label claims it is organic, is it really? Is it possible for a false statement to be on a label? Is the price I’m paying justified? Although there are already many certificates that seem to guarantee the origin of the product, there is only one which has definitive rules for growers to follow. 

The GLOBALG.A.P. is a food safety standard developed to regulate food production processes from micro to macro level of producing. GLOBALG.A.P. certificate can provide the customer a complete transparency of the food production process, from the farm to its final product.

How to prepare for a new kitten in your home.

 How to prepare for a new kitten in your home.

Kittens have a sophisticated sense of smell and they learn a lot about their world through their nose. If it is possible, leave an item of clothing or towel from your home with your kitten for a few days before you collect them. When you do collect them, take this item with you, the familiar scents will help your kitten to settle into their new home quicker.

 It is important not to overwhelm your new kitten on arrival as they will need time to adjust. Provide  somewhere to hide, such as a cardboard box with a soft toy. The ticking of an alarm clock may also be comforting as it mimics the sound of their mother’s heart.

You may wish to keep your kitten in one room of the house to begin with, and slowly introduce them to the rest of the house. It is important that your kitten has a safe quiet place where their water and feeding bowls can be left, and another for their litter tray.

Cats can feel vulnerable when they are eating and toileting, so performing these activities in a sheltered area will help to reduce stress.  Cats are not naturally social animals and generally prefer to be alone. However, cats can live together happily with the right measures in place. If you have more than one cat, they should each have their own bowls, litter trays and toys, at least one for each cat and an extra. Any competition over resources could cause stress and dominance issues between your pets. 

 First Vet Visit ;It is always a good idea to make an appointment with your chosen vet as soon as possible. The vet will give your new kitten a full physical examination, including listening to their heart and lungs and checking their eyes, ears and mouth.


They will be looking for signs of parasitic infection, illness and birth defects. This first visit is a great time to ask specific questions about your kitten’s health and well-being, such as which is the best type of food to feed and when should you book in for their vaccinations. Depending on the age and health of your kitten, your vet may recommend a vaccination course is started at this first visit.

Fleas and Worms Kittens commonly are infected by parasites, and due to their small size and immature immunity these parasites can have a large impact on their health. Your veterinary surgeon will be able to give you advice on products suitable for your kitten’s age and weight. Dog flea products should never be used on a cat as some can be extremely toxic to cats.

RESEARCH: Ebola virus found in bat in West Africa for the first time.

RESEARCH: Ebola virus found in bat in West Africa for the first time.The Ebola virus has been found in a bat in Liberia, the country’s government and scientists with Columbia University’s Mailman School of Public Health announced this week. The discovery marks the first time the virus has ever been found in a bat in West Africa, though it has previously been found in bats in Central Africa, according to the Tech Times. The university's Mailman School of Public Health said in a statement Thursday that scientists found “genetic material from the virus and ebolavirus antibodies” in a greater long-fingered bat located in the Nimna District of Liberia. Preliminary testing indicates a specific strain of the virus — Zaire ebolavirus — may have been found in the bat. Zaire ebolavirus is “responsible for causing the West African Ebola epidemic which infected nearly 30,000 people between 2013 and 2016,” according to the Mailman School of Public Health's statement.

AGRIBUSINESS: How to revive a new born calf.

AGRIBUSINESS: How to revive a new born calf. Calves are at a relatively high risk of mortality as soon as they are born. When they hit the ground, and their navel cord is severed, they need to obtain oxygen through the lungs. They do this by starting to breath. However sometimes a difficult or prolonged calving can result in trauma or a weak calf, and they need a bit of help kicking it into gear. A newborn calf's nostrils and mouth are covered with mucous which can affect their breathing, and there are multiple ways a farmer can help to clear them. 1) Stimulate the nostrils to make the calf cough or sneeze. If you tickle the calf’s nostrils with something small, soft and clean you can bring about a cough or a sneeze to clear away the mucous. Usually this is done with straw or a gloved fingertip. Be careful though - if it isn’t clean, small enough to enter the nostril or soft enough, it could injure or inflame the nose. 2) Cold stimulation of the calf. Pouring cold water over the head or into the ear of a newborn calf can bring about head shakes and coughing to clear fluid from their throat. This sudden gush of cold water will come as a shock and is a pretty abrupt welcome into the world for a newborn calf . 3) Aspiration: You can inflate the lungs of a newborn calf by aspiration in a few ways. One way is to insert a soft tube into the nostril. Another is by placing a gas mask over the snout of the calf. This practice prompts the calf to snort like the straw method, however is comes with the added benefit of having the added momentum of a lungful of air. AGRIBUSINESS: How to revive a new born calf.