RESEARCH: Eyes of Creutzfeldt-Jakob disease( CJD) patients show evidence of prions.

RESEARCH: Eyes of Creutzfeldt-Jakob disease patients show evidence of prions. Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, fatal brain disorder. It affects about one person in every one million per year worldwide; in the United States there are about 350 cases per year. CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs) or prion diseases. A prion—derived from “protein” and “infectious”—causes CJD in people and TSEs in animals. Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges when examined under a microscope. CJD is the most common of the known human TSEs. CJD usually appears in later life and runs a rapid course. The typical onset of symptoms occurs at about age 60, and about 70 percent of individuals die within one year. In the early stages of the disease, people may have failing memory, behavioral changes, lack of coordination, and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur. There are three major categories of CJD. 1)In sporadic (sCJD), the disease appears even though the person has no known risk factors for the disease. This is by far the most common type of CJD and accounts for at least 85 percent of cases. 2)In hereditary CJD, the person may have a family history of the disease and test positive for a genetic mutation associated with CJD. About 10 to 15 percent of cases of CJD in the United States are hereditary. 3) in acquired CJD, the disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. There is no evidence that CJD is contagious through casual contact with someone who has CJD. Since CJD was first described in 1920, fewer than one percent of cases have been acquired CJD. A type of CJD called variant CJD (or vCJD) can be acquired by eating meat from cattle affected by a disease similar to CJD called bovine spongiform encephalopathy (BSE) or, commonly, “mad cow” disease. A new study, researchers at University of California San Diego School of Medicine with colleagues at the National Institutes of Health and UC San Francisco, report finding tell-tale evidence of the condition's infectious agent in the eyes of deceased sCJD patients, making the eye a potential source for both early CJD detection and prevention of disease transmission. In the November 20 issue of the journal mBio, co-corresponding author Christina J. Sigurdson, DVM, PhD, professor of pathology at UC San Diego and UC Davis, and colleagues discovered high levels of prions in the eyes of 11 deceased patients, all with confirmed sCJD. Almost half of sCJD patients develop visual disturbances, and its a known fact that the disease can be unknowingly transmitted through corneal graft transplantation.

Tweets show daily rhythm of our thinking.

Tweets show daily rhythm of our thinking. A study of 800-million tweets finds distinct daily cycles in our thinking patterns. Our mode of thinking changes at different times of the day and follows a 24-hour pattern, according to new findings published in PLOS ONE. University of Bristol researchers were able to study our thinking behaviour by analysing seven-billion words used in 800-million tweets. Researchers in artificial intelligence (AI) and in medicine used AI methods to analyse aggregated and anonymised UK twitter content sampled every hour over the course of four years across 54 of the UK's largest cities to determine if our thinking modes change collectively. The researchers revealed different emotional and cognitive modalities in our thoughts by identifying variations in language through tracking the use of specific words across the twitter sample which are associated with 73 psychometric indicators, and are used to help interpret information about our thinking style.

READING DOGS HELP CHILDREN STUDY.

“Reading” Dogs Help Children Learn | The Bark Reading is indeed fundamental, but for many, acquiring the skill is daunting. Fortunately, thanks to some innovative programs and cooperative dogs, the challenge is getting easier to meet. Across the nation, dogs are lending their ears, and thousands of children who need extra help with reading and interpersonal communication couldn’t be happier. Imagine this scene, described by Brooklyn’s Good Dog Foundation founder and executive director, Rachel McPherson: “For each session, the dog and the child-tutor settle down onto a blanket-covered pad on the floor in a corner of the school media center or in the library. Either the dog picks out a book or the child selects a picture book, brings it to the dog, holds it flat and begins to read.” Though the children believe they are teaching dogs to read, in fact, with the dog as a comfortable, attentive audience (and an occasional gentle assist from the dog’s adult volunteer partner), they are actually teaching themselves. As far as the child is concerned, however, reading is about the dog, not about the child. No pressure. No embarrassment. No humiliation. Learn the technique and those involved;http://thebark.com/content/reading-dogs-help-children-learn