BAT'S IMMUNITY; A NEW MODEL FOR PREVENTING DISEASES IN MAN.

Bats are a natural host for more than 100 viruses, some of which are lethal to people, including Middle Eastern Respiratory Syndrome (MERS), Ebola and Hendra virus, however, interestingly bats do not get sick or show signs of disease from these viruses. A new study has revealed the distinct ability in bats,that enables them carry disease-agents and still remain unaffected by such organisms.For the first time researchers have uncovered a unique ability in bats which allows them to carry but remain unaffected by lethal diseases. Unlike humans, bats keep their immune systems switched on 24/7 and scientists believe this could hold the key to protecting people from deadly diseases like Ebola. The research published in the Proceedings of the National Academy of Sciences (PNAS), this new research examines the genes and immune system of the Australian black flying fox. Whenever our body encounters a foreign organism, like bacteria or a virus, a complicated set of immune responses are set in motion, one of which is the defense mechanism known as innate immunity,leading bat immunologist at CSIRO's Australian Animal Health Laboratory Dr Michelle Baker said. The team focused on the innate immunity of bats with particular reference to the role of interferons -which are essential for innate immune responses in mammals and to understand what's special about how bats respond to invading viruses. It was discovered that bats only have three interferons which is only a fraction -- about a quarter -- of the number of interferons found in people.This is surprising given bats have this unique ability to control viral infections that are lethal in people and yet they can do this with a lower number of interferons. The team also compared two type 1 interferons -- alpha and beta.The research showed that bats express a heightened innate immune response even when they were not infected with any detectable virus. Man and mice activate their immune systems only in response to infection, the bats interferon-alpha is constantly 'switched on' acting as a 24/7 front line defense against diseases In other mammalian species, having the immune response constantly switched on is dangerous because it's toxic to tissue and cells- whereas the bat immune system operates in harmony. The important role bats play in the eco-system as pollinators and insect controllers is recognized, bats are also increasingly demonstrating their worth in potentially helping to protect people from infectious diseases.