Mosquitoes spread viruses faster than thought

Researchers say discoveries about virus development in mosquitoes might someday help stop disease transmission. Researchers at the University of Missouri have found viruses spread in the bodies of mosquitoes much quicker than previously thought. 

 "Previously, the common understanding was that when a mosquito has picked up a virus, it first needs some time to build up inside the mid-gut, or stomach, before infecting other tissues in the mosquito," said Alexander Franz, an assistant professor in the Department of Veterinary Pathobiology in the MU College of Veterinary Medicine and the study’s corresponding author. "However, our observations show that this process occurs at a much faster pace; in fact, there is only a narrow window of 32 to 48 hours between the initial infection and the virus leaving the mosquito’s stomach.

 For this field of research, that revelation is eye opening." continue.

VETERINARY MEDICINE: Feline morbilli virus.

VETERINARY MEDICINE: Feline morbilli virus. Feline morbillivirus (FeMV) was first reported in domestic cats in Hong Kong and China in 2012, and has since has been detected in Japan, Europe and the Americas. It was named as the seventh species in the genus Morbillivirus, alongside important pathogens of humans and animals such as measles virus and canine distemper virus. Despite a widespread distribution, like FcaGHV1 it is unclear whether FeMV causes disease in cats. Of particular interest to the veterinary community, however, is a link that has been suggested in several reports between FeMV and tubulointerstitial nephritis, the pathological manifestation of feline Chronic kidney disease.

VETERINARY MEDICINE: Emerging viruses in cats.

VETERINARY MEDICINE: Emerging viruses in cats.Emerging infectious diseases comprise a substantial fraction of important human infections, with potentially devastating global health and economic impacts A 2008 paper in Nature described the emergence of no fewer than 335 infectious diseases in the global human population between 1940 and 2004. In the veterinary field, just as in the medical field, advanced molecular techniques and sophisticated computer-based algorithms for genetic sequence assembly and analysis have revolutionized infectious disease research. They have also raised important questions, as the potential pathogenic role of novel viruses can be difficult to determine. What is well understood is that novel viruses may contribute to diseases that are major causes of feline morbidity and mortality, including cancer and chronic kidney disease (CKD). A state-of-the-art review article published in the Journal of Feline Medicine and Surgery this month focuses on two novel viruses that have the potential to negatively impact feline health and welfare globally -- gammaherpesvirus and morbillivirus. For many years, domestic cats were identified as the natural host for just a single herpesvirus, feline herpesvirus 1, which is a common cause of ocular and upper respiratory tract disease. In 2014, a targeted virus discovery programme, prompted by the clinical observation that cats develop the types of cancer that, in humans, are caused by gammaherpesviruses, identified Felis catus gammaherpesvirus 1 (FcaGHV1). The first gammaherpesvirus known to infect domestic cats, FcaGHV1 is widely endemic; studies suggest that cats can be infected from 2 months of age, and that most adult cats are persistently infected. What is not yet known is whether FcaGHV1 has any pathogenic role in cats. Comparative evidence, however, suggests that while gammaherpesvirus infections typically remain subclinical, in certain circumstances, often after many years of infection, they can cause severe and frequently fatal disease.

HOW THE DISTEMPER VIRUS JUMPS TO OTHER SPECIES.

Distemper has been noted to affect tigers,lions and some bears .See(http://veterinarymedicineechbeebolanle-ojuri.blogspot.com.ng/2016/04/distemper-virus-and-tigers.html). Canine distemper, a viral disease that has infected the lions of Tanzania's Serengeti National Park, appears to be spread by multiple animal species, according to a study published by a transcontinental team of scientists. In 1994, a mysterious neurological ailment wiped out 30-percent of the lion population in the Serengeti, one of the largest wildlife regions in the world. Scientists determined it was canine distemper, a disease previously thought to infect only dogs, coyotes and a small number of other mammals. Evidence suggested the lions had contracted the virus from dogs living in villages and settlements nearby. A domestic dog vaccination campaign was launched to curb the infection's spread. It worked--among dogs, at least. After analyzing three decades of blood serum data collected from lions and domestic dogs, the researchers discovered that the virus continues to circulate in the lion population while significantly declining among dogs. A new research by researchers in Cornell university have shown how the virus jumps to other species, a key mutation in the protein shell of canine parvovirus -- a single amino acid substitution -- plays a major role in the virus' ability to infect hosts of different species. Canine parvovirus, or CPV, emerged as a deadly threat to dogs in the late 1970s, most likely the result of the direct transfer of feline panleukopenia or a similar virus from domesticated cats. CPV has since spread to wild forest-dwelling animals, including raccoons, and the transfer of the virus from domesticated to wild carnivores has been something of a mystery. Colin Parrish, the John M. Olin Professor of Virology and director of the Baker Institute for Animal Health at Cornell University co-authored a research paper, published in the Journal of Virology, with Susan Daniel, associate professor in Cornell's Robert Frederick Smith School of Chemical and Biomolecular Engineering, which contends that a key mutation in the protein shell of CPV -- a single amino acid substitution -- plays a major role in the virus' ability to infect hosts of different species. There's an initial attachment, which is probably relatively weak," he said. "The thing just grabs on and holds on a little bit, sort of like using your fingertips. And then it looks like there's a second attachment that is much stronger, where it's like you grab on and hold on with both hands and won't let go." The second event, is structural interaction that occurs in a small proportion of the binding cases, seems to be critical," he said. "We think that it actually causes a change in the virus, that it triggers a small shift in the virus that actually makes it able to infect successfully." One of Daniel's specialties is the investigation of chemically patterned surfaces that interact with soft matter, including biological materials such as cells, viruses, proteins and lipids. Her lab has pioneered a method called single-particle tracking -- placing artificial cell membranes into microfluidics devices, fabricated at the CNF, to study the effect of single virus particles on a variety of membrane host receptors, in this case from both dogs and raccoons.

DISEASE TRANSMISSION ON FARMS AND COMMON DISINFECTANTS.

Unrestricted movements to farms,across farms and from other farms to your farm. Contamination of feed and water with droppings. Contact with wild birds,infected birds and exotic birds. Contaminated farm equipment and tools. Soiled hands. contaminated plastic and paper crates. Inhaling infected Respiratory droplets. All these routes of transmission can be curtailed with strict bio security protocol; which should include isolation ,washing, and disinfection .The pathogens are usually inactivated by potent disinfectants that contain active ingredients that destroys these pathogens; these include lipid solvents,saponated cresols,phenol compounds,formaldehyde,lodine compounds,hypochlorite, and ammonia compounds. There are various compounds with varied potency,hence its imperative to tailor your disinfectants to match the pathogens to ensure efficacy.

FOOD SAFETY.

Food safety refers to methods,procedures and protocols that are practiced in food industry.These procedures/protocol are put in place during processing, packaging and transportation. Food safety is very important to human health because it prevents food-borne diseases that could be fatal.Food safety prevents hazards in food that cause injury,illness and sometimes death.These hazards could be physical,biological or chemical in nature , found in food and drinks, have varying impacts on human health.The susceptibility of individuals to these hazards vary with children being major subjects followed by elderly older than 65, then pregnant women and lastly immune compromised individuals. The physical hazard include stones,broken glass,plastic cuts,jewelry,rings,pieces of fabric(shredding table cloth ) and boards e.t.c.The hazard usually occur during processing,packing and storage.The food processors are usually the major cause of these form of hazard; the work unit,tools and personal hygiene have all being pinned as sources of food hazard. Chemical hazard include poisonous substances,chemicals ,soaps,detergents or cleaning liquids that are spilled during food processing.Pesticides,rodenticides and paints have also being fingered as hazard in food industry. Biological hazards are microorganism ,which include bacteria,viruses and parasites.The parasites are usually tiny worms in beef,pork and fish; these parasites are usually found in contaminated water,used in processing.Bacteria grow in food under certain conditions such as low temperatures,fecal contamination,or cross contamination which result in food spoilage and food borne illness.These bacteria contaminate food during processing handling and storage. Viruses in food usually contaminate food during processing ,these are usually from food processors that are coughing,sneezing,and picking nose.These can be prevented by maintaining high level of hygiene by food processors. Food borne illness can be prevented by implementing the following ;1) high standard of personal hygiene. 2)temperature control. 3) preventing of cross contamination between various food items. 4)cleaning of utensils,working area and cutting boards. 5) proper packaging and storage. Personal hygiene will include washing hands before handling meat,after using toilet and after handling various raw food.The food processor must not wear jewelry and accessories that can easily drop off during production, nails must be cut short and clean,hair must be covered and neat clean clothing must be worn. The processor must wear clean overall,gloves and clean working shoes.The health status of food processors play a vital role in the level of safety of the food ,hence processors that are ill, coughing,sneezing, vomiting or have diarrhea should not handle food.Food operators must undergo regular checkup to ascertain health status,any case tuberculosis,hepatitis,HIV/AIDS should be reported. Hand washing plays an important role in food safety and the benefits cannot be overemphasized; hand washing removes microorganisms and should be done throughout the day.