CANINE CANCER TRIALS AND CANCER TREATMENT IN MAN.

MELBOURNE scientists say a new canine cancer trial has produced exciting results that could lead to a breakthrough in human treatment.Dr Noam Pik, head of the veterinary division at West Melbourne biotechnology research group Biotempus, is leading the free clinical trial and said early results were mind-blowing The 12-month trial, which is being conducted at 20 veterinary clinics around Australia, was launched in December and according to Dr Pik, several dogs had already shown signs of remission. Dr Pik said dogs were given a single dose of chemotherapy — a tablet — that did not target the tumour, but attacked (T-Regulatory) cells within the patient’s own immune system.If this trial proves effective, they plan to offer this service to canine patients within 24 months and then continue to humans. These cells suppressed the natural cancer-fighting mechanism of other (T-Effector) cells in the immune system ,if the T-Regulatory cells can be selectively killed, the T-Effector cells can get on with the job of eliminating cancer undisturbed. This method has been researched before but Dr Pik’s team has discovered a way to predict when the suppressor cells are most vulnerable — the optimum time to administer the chemo and kill the cells. The team discovered the immune system moves in cycles and can be mapped. Dogs are required to give blood samples every second day for up to three weeks, so experts can track their immune cycle and identify the best time to administer the drug. The last decade of research has shown considerable progress in the field of immunotherapy — using the patients’ own immune system to fight the cancer. The contribution of the tumor micro-environment is immense and has been previously largely underestimated. Thus, we believe it is important to aim treatment at both the tumor itself and the tumor environment with the aim of achieving more effective and durable cancer treatments. The chemo tablets cost less than $5, the treatment could potentially slash the cost of canine cancer treatment. The low-dose tablet is strong enough to correct the immune imbalance without the harsh side effects usually associated with chemo, such as nausea.

DNA KIT FOR DOGS TO ANALYSE DISEASE RISK AND TRACE GENETIC TREE.

A startup is kicking off and its using dog's saliva in its tool to give dog owners the disease of their breeds and trace the pedigree.The startup called EMBARK is a DNA KIT that will give information to owners about disease risk and also trace ancestry. The company founders rolling out the product says the real objective is that the research will help to conduct various tests with the DNA samples and use the potential of dog genetics to deliver advancements in human health. Dogs and humans share many of the same kinds of conditions, hence by studying the genetics of diseases in dogs, scientists may be able to figure out how these originate in humans. The kit by engaging mass numbers of dog owners, will provide data that will unlock the potential of the dog as a model system and that is the real idea behind Embark. The founders have figured out that it’s a lot easier to fund research if study participants — or their owners — pay for the privilege of taking part in a study. Cornell University School of Veterinary Medicine has already agreed to be an Embark research partner, and the company intends to conduct its own studies, under the guidance of Adam Boyko, Embark's chief science officer, a dog geneticist at Cornell University, and Ryan’s brother. This kit will provide a framework for breeders and dog owners and will also be an important planning tool in terms of insurance.Client education about various diseases ,management and life expectancy of certain conditions will really help to address issues of breeding and animal welfare. The snag about this test will be the limiting of certain breeds and excessive breeding of other breeds which will over time phase out some breeds. # data bank #gene pool # gene bank # breeders # genetics.

Green entrepreneurs tackle Indonesia's growing trash mountains .

ng-trash-mountains/#iRKkEwXYmmRuW319.15">Green entrepreneurs tackle Indonesia's growing trash mountains | NewsDaily Some residents of the Indonesian capital, Jakarta, frustrated by the mounting trash problem across the sprawling metropolis, have started taking matters into their own hands. Hamidi, a young “green entrepreneur” became so concerned by the overflowing Jakarta city dump that he began turning discarded plastic into fuel. “At the very beginning I just wanted to start a business,” said Hamidi, who started his waste-to-energy initiative a year ago in Tangerang, a satellite city about 25 km (15 miles) west of Jakarta. Read more at http://newsdaily.com/2016/03/green-entrepreneurs-tackle-indonesias-growing-trash-mountains/#5ZWsDpmC5ixi3cDx.99

Meat turns up the heat as livestock emit greenhouse gases.

Studies by Carnegie institution shows that eating meat contributes to climate change, due to greenhouse gasses emitted by livestock. The research shows that livestock emissions are on the rise and that beef cattle are responsible for far more greenhouse gas emissions than other types of animals. The tasty hamburger has been fingered as a major culprit and It might be better for the environment if meat consumption is cut down. The effect of eating pork or chicken instead of beef has a much positive impact on environment . Carbon dioxide is the most-prevalent gas when it comes to climate change. It is released by vehicles, industry, and forest removal and also comprises the greatest portion of greenhouse gas . The methane and nitrous oxide are also greenhouse gasses and account for approximately 28 percent of global warming activity. Methane and nitrous oxide are released, in part, by livestock. Animals release methane as a result of microorganisms that are involved in their digestive processes and nitrous oxide from decomposing manure. These two gasses are responsible for a quarter of these non-carbon dioxide gas emissions and 9 percent of total greenhouse gas emissions overall. The researchers found a difference between livestock-related emissions in the developing world, which accounts for most of this increase, and that released by developed countries. This is expected to increase further going forward, as demand for meat, dairy products, and eggs is predicted by some scientists to double by 2050. By contrast, developed countries reached maximum livestock emissions in the 1970s and have been in decline since that time. Feeding manipulation and different management methods have demonstrated changes in levels of gas released.Cows fed on hay and pasture burp more due to ruminal activity on the feed thus releasing more methane than other cows on grains and corn where there is less emission.

DUNG BEETLES AND GREENHOUSE EMISSIONS.

Cattle contributes to global warming by burping and farting large amounts of greenhouse gases and Some of the same gases are also emitted from cow pats on pastures. Researchers have found that beetles living in cow pats may reduce emissions of the greenhouse gas, methane. By digging around in their food, dung beetles like Aphodius pedellus may aerate cow pats and thereby modify methane emissions which will prevent climatic changes according to a study published in the journal PLoS ONE. Agriculture is one of the biggest sources of the greenhouse gases responsible for global warming and among these, cattle farming for meat and milk are major sources of methane, a gas with a potent warming effect. A large percentage of this methane comes from the guts of ruminating cattle, but some escapes from dung pats on pastures. Cow pats offer a prime food for a large number of organisms there are probably as many beetle species living in dung . The dung beetles live and spend most of their entire lives within the dung pats. The beetles exert much of their impact by simply digging around in the dung, and the tunneling by beetles seems to aerate the pats. This will have a major impact on how carbon escapes from cow pats into the atmosphere. This aeration prevents the production of methane,thus preventing the warming effect of the gas.

Feeding cattle with garlic reduces methane emission.

. Cattle produce a lot of methane which is a green house gas,thus contributing to global warming. The feeding pattern of the cattle results in series of burps/flatus generating a lot of methane,which in turn causes climatic changes. A school of thought suggests cutting down on beef production or totally stop the production,but the benefits of the cattle cannot be ignored and since there are no acceptable substitutes other options must be proposed.. The vegan group advocates more converts,but many people are unwillingly to rock the boat. The livestock industry accounts for over 15% of the total greenhouse emissions,even higher than that of the transport sector,thus adjustments must be made in livestock sector. These approaches will involve improved genetic selection through breeding, modification of dietary composition, rumen microbial manipulation and vaccines against the methanogenic bacteria that generate the methane in these animals and various other techniques. It is possible that among the approaches or with a combination of approaches there might be a way to reduce the global burden of methane emissions from livestock. The changes in nutrition and feed play a vital role on methane production by ruminants thus manipulating the diet of these animals to reduce absolute methane emissions is the key to reduce these emissions.There has been various modifications to feed/feeding pattern by various feed companies all with varying degrees of success such as DSM, a Dutch science firm, developed a powder that can be added to feed and inhibits the production of methane in the cow’s rumen. According to findings published in the National Academy of Sciences, researchers from DSM and Penn State University studied the effect of the supplement on 48 dairy cows over the course of 12 weeks and found promising results. They observed that cows whose feed contained the powder produced 30 percent less methane and gained weight compared to cows who ate typical diets and milk production was not changed. Feed intervention has also been done by German researchers who created a methane-reducing pill, and scientists in Wales found that cows who consumed garlic produced 50 percent less gas although the impact of garlic-based diet on the taste of milk or meat is largely unknown . Feed supplements,additives ,changes in diet and management of herd could hold answer to this climatic change without compromising the protein source and major source of milk and milk products in man.

GOAL SETTING.

Think yourself clear,set a course. Learn from the pro!!!