FRUIT PEELS AS TREATMENT PROTOCOL FOR WOUND REPAIR IN DIABETIC PATIENTS.

Oral dose of Citrus Peel Extracts Promotes Wound Repair in Diabetic Rats.This research was carried out by M. Ahmad, M.N. Ansari, A. Alam and T.H. Khan and reported in science alert. Diabetic patients wound healing is slower than the healthy individuals. Three citrus peel extracts; Lemon (Citrus limon), Grapes fruits (Citrus paradise) and Orange (Citrus sinensis) promote wound healing in experimental animals. This study investigated the effect of oral treatment with citrus peel extracts on wound repair of the skin of diabetic rats. The extracts were estimated for vitamin C and total carotenoid contents prior to animal study. Diabetes mellitus was induced in rats by intraperitoneal injection of a single dose of streptozotocin (STZ, 75 mg kg-1 b.wt.). One week after diabetes induction, full thickness excision wounds were made in hyperglycemic rats and were divided groups, each containing 6 rats. The different test group animals were treated with different citrus peel extract orally at the dose of 400 mg kg-1 body weight daily for 12 days. The blood glucose, body weight and rate of wound closure of each rat were measured every 3rd day during the experimental period. At the end of experiment, granular tissues of wounds were removed and estimated for hydroxylproline and total protein content. The results showed significant reduction in blood glucose and time to wound closure. Tissue growth and collagen synthesis were significantly higher as determined by total protein and hydroxyl proline content. From our experimental data, we propose that oral administration of citrus peel extracts has a therapeutic potential in the treatment of chronic wounds in diabetes.

STRANGLES IN HORSES.

Strangles in horses caused by streptococcus equi,is a very contagious respiratory disease.All horse ages can be affected but foals and travel horses are very susceptible.The incubation period is 2 weeks but the affected horses still shed bacteria for longer periods,thus their can be new incidence on farm after index case.The form of infection is direct or indirect route, the direct route usually through water buckets where bacteria can survive for long periods of time.10% of affected horses become carriers. The common signs are fever,nasal discharge,cough,depression,lack of appetite,enlarged lymph nodes that form abscess that eventually ruptures.The affected horses may or may not show classical signs aside from fever,hence the conditions can go un diagnosed on the farm. There are certain complications in strangles infection which makes condition fatal; 1) Abscesses can be formed in other body organs referred to as "bastard strangles".2) Purpura haemorrhagia ;where the blood vessels are damaged and can be identified by swollen limbs,blood blisters around eyes and lips.This can lead to death because of circulatory failure. Prevention. 1) vaccination. 2) separate/isolate horses by ages and susceptibility status. 3) strict bio security protocol. 4) limit number of horses/ stable/barn in the farm. Treatment. 1) isolate affected horses. 2) use dedicated feed/water bowl. 3) restrict movement, do not turn on pasture. 4) proper manure management/disposal. 5)antibiotics. 6) wound treatment to prevent fly strikes. 6) vitamin supplement .