New NDV-H5NX avian influenza vaccine has potential for mass vaccination of poultry.

Researchers have developed and tested a new vaccine that protects chickens and other poultry from multiple strains of avian influenza found in the U.S., including H5N1, H5N2 and H5N8. A team of researchers at Kansas State University, in collaboration with Garcia-Sastre of the Icahn School of Medicine at Mount Sinai, has developed a vaccine that protects poultry from multiple strains of avian influenza found in the U.S., including H5N1, H5N2 and H5N8. The vaccine has the potential to be administered through water or into embryonated eggs, making it easier for poultry producers to vaccinate flocks.The vaccine, called NDV-H5Nx, protects chickens and likely other poultry against the three recently introduced U.S. avian influenza strains H5N1, H5N2 and H5N8, as well as against Newcastle disease virus -- a virus that naturally affects poultry. Avian influenza killed millions of chickens and turkeys in the U.S. in spring and summer 2015, leading to billions in lost revenue for the U.S. poultry industry. The NDV-H5Nx vaccine also has the potential to be administered to millions of birds at a time through water, said Jürgen Richt, Regents distinguished professor of veterinary medicine, director of the U.S. Department of Homeland Security's Center of Excellence for Emerging and Zoonotic Animal Diseases at Kansas State University and one of the researchers involved in the discovery. "The vaccine we produced is a live vaccine, which means it replicates in birds," Richt said. "Because it's live, we believe that the vaccine could be sprayed into the air or put in the water supply so that when the chickens need a drink, they could be vaccinated. A poultry farm could vaccinate all of its birds in a single day because all living creatures need water to live." The vaccine also has potential to be administered to developing chicks in eggs, resulting in offspring being automatically vaccinated for the diseases, said Wenjun Ma, Kansas State University assistant professor of diagnostic medicine and patho biology and one of the researchers involved. The NDV-H5Nx vaccine has the ability to differentiate infected from vaccinated animals, or DIVA. This compatibility is critical for the U.S. poultry industry because it provides evidence to trade partners that poultry have been vaccinated and is free of H5, Richt said. H5 vaccines currently on the market require that each chicken be injected by hand. Many poultry operations have millions of birds and it would take many hours to vaccinate every chicken, Richt said.This is a major advantage as many birds can be vaccinated per time. Story source; science daily.