Researchers have generated six Zika virus antibodies.

Researchers have generated six Zika virus antibodies.Researchers have generated six Zika virus antibodies that could be used to test for and possibly treat a mosquito-borne disease that has infected more than 1.5 million people worldwide. The antibodies "may have the dual utility as diagnostics capable of recognizing Zika virus subtypes and may be further developed to treat Zika virus infection," corresponding author Ravi Durvasula, MD, and colleagues report in a study published in the journal PLOS ONE. Zika is spread mainly by mosquitos. Most infected people experience no symptoms or mild symptoms such as a rash, mild fever and red eyes. But infection during pregnancy can cause miscarriages, stillbirths and severe birth defects such as microcephaly. Zika virus is a textbook example of an emerging disease that appears quickly, often in remote areas with little or no public health infrastructure. There is no effective vaccine or drug to treat the disease.

RAPID MUTATION OF THE ZIKA VIRUS.

According to Times report,Scientists are questioning how the zika virus spreads. Until recently, experts believed Zika was a relatively benign virus spread by mosquitoes. But now that it’s been linked to more than 1,000 microcephaly cases, scientists have taken a closer look, recently declaring it “scarier than we initially thought,” as one U.S. health official put it this week. The Centers for Disease Control and Prevention (CDC) recently announced it is now absolutely confident that Zika causes microcephaly—a connection that was suspected but not proven. It also appears to be linked to other disorders like Guillain-Barré syndrome and other autoimmune syndromes. The virus, experts now know, can be transmitted through sex. In a new twist, experts are questioning the idea that mosquitoes are the primary cause of transmission. In a new study, researchers at the University of California, Los Angeles (UCLA), looked at sequences of the Zika virus over decades and found notable changes in the virus over time, suggesting that the virus’ ability to mutate is a reason why it is able to trigger different types of disease. They also noticed that the sequenced strains of Zika from mosquitoes do not match all the strains in humans from this outbreak. This suggests that more people than was expected may be getting the virus some other way. The UCLA team partnered with Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing and compared 40 strains of Zika from past outbreaks as well as strains from the current one. The researchers analyzed some strains collected from people, some from monkeys, and some from mosquitoes. When sequences of the viruses were compared, the scientists noted a variety of differences between them. The curious angle, the researchers note, is that the strains of the virus collected from humans in this outbreak haven’t matched the strains seen in mosquitoes.“We haven’t found any human sequences in the mosquito in recent history, noted the researchers. The team thought they haven’t been looking hard enough. and If we can’t find them, it brings into question whether the mosquito is the primary mode of transmission in the current epidemic. The researchers suggest, that other modes of transmission, like sex, may play a bigger role. The cases of sexually transmitted Zika— was revealed it can be spread via anal sex as well as vaginal sex The CDC released precautions that people who are in areas of active Zika transmission need to practice safe sex, and abstinence may be recommended during pregnancy. There are currently no areas of active Zika transmission in the U.S., but the virus is spreading locally in Puerto Rico. The researchers of the current study say there’s much more that needs to be done before scientists will fully understand Zika. The team plans to continue studying the strains involved in the ongoing outbreak as a way to identify possible targets for drug and vaccines. The need to broaden our thinking about how this disease can be transmitted and how to stop it is very vital. culled from time.com

Yellow fever outbreak first reported in Angola kills 21 people in Congo.

Yellow fever outbreak that killed hundreds in Angola appears to be moving to neighboring Congo, where it has left at least 21 people dead. The Democratic Republic of Congo reported the deaths this week, the World Health Organization said in a statement that between January and March, at least 151 people were suspected of having the disease in the Congo. Some of the cases were detected in areas bordering Angola and "were imported" from there, according to the organization. At least 225 deaths have been reported in Angola as of this week, the nation's worst yellow fever outbreak in three decades. Most of the cases have been in the capital, Luanda. "The report of yellow fever infection in travelers returning from Angola ... highlights the risk of international spread," the WHO statement said. Yellow fever is transmitted by two types of mosquitoes, one of which is responsible for the Zika virus that has ravaged the Americas.The yellow fever virus is transmitted when a mosquito bites an infected monkey and then bites a human. Symptoms include fever, muscle pain, nausea, vomiting and loss of appetite, and can be confused for malaria or other mosquito-borne illnesses. A small percentage of infected people experience a second phase within 24 hours of becoming ill. It comes with more advanced symptoms, including jaundice, hemorrhaging and bleeding from the eyes, nose and mouth. At least half of the patients who get the second phase of the disease die within 10 to 14 days. There is no treatment for yellow fever, but patients can get supportive care.

ZIKA VIRUS LINKED TO BRAIN DISORDER IN ADULTS.

Zika has already been linked with the autoimmune disorder Guillain-Barre syndrome, which attacks peripheral nerves outside the brain and spinal cord, causing temporary paralysis that can in some cases require patients to rely on respirators for breathing. Scientists in Brazil have uncovered a new brain disorder associated with Zika infections in adults: an autoimmune syndrome called acute disseminated encephalomyelitis, or ADEM, that attacks the brain and spinal cord. The new discovery now shows Zika may provoke an immune attack on the central nervous system as well and this findings add to the growing list of neurological damage associated with Zika. According to the World Health Organization, there is a strong scientific consensus that, in addition to Guillain-Barre, Zika can cause the birth defect microcephaly, though conclusive proof may take months or years. Microcephaly is defined by unusually small heads that can result in developmental problems. In addition to autoimmune disease, some researchers also have reported patients with Zika infections developing encephalitis and myelitis – nerve disorders typically caused by direct infections in nerve cells. Acute disseminated encephalomyelitis, or ADEM, typically occurs in the aftermath of an infection, causing intense swelling in the brain and spinal cord that damages myelin, the white protective coating surrounding nerve fibers. It results in weakness, numbness and loss of balance and vision, symptoms similar to multiple sclerosis. The scope of study is small, it may provide evidence that in this case, the virus has different effects on the brain than those identified in current studies,” Dr. Maria Lucia Brito, a neurologist at Restoration Hospital in Recife, Brazil. The study involved 151 patients who visited her hospital between December 2014 and June 2015. All had been infected with arboviruses, the family of viruses that includes Zika, dengue and chikungunya. Six of these patients developed symptoms consistent with autoimmune disorders. Of these six, four had Guillain-Barre and two had ADEM. In both ADEM cases, brain scans showed damage to white matter. ADEM symptoms typically last about six months. All six patients tested positive for Zika, and all had lingering effects after being discharged from the hospital, with five patients reporting motor dysfunction, one with vision problems, and one with cognitive decline. Read more at http://newsdaily.com/2016/04/brazilian-scientists-find-new-zika-linked-brain-disorder-in-adults/#3W9X77ZDhHxA6TKB.99

ZIKA VIRUS AND NERVE CELL INFECTION.

Top Zika investigators now believe that the birth defect microcephaly and the paralyzing Guillain-Barre syndrome may be just the most obvious maladies caused by the mosquito-borne virus. Fueling that suspicion are recent discoveries of serious brain and spinal cord infections – including encephalitis, meningitis and myelitis – in people exposed to Zika. Evidence that Zika’s damage may be more varied and widespread than initially believed adds pressure on affected countries to control mosquitoes and prepare to provide intensive – and, in some cases, lifelong – care to more patients. The newly suspected disorders can cause paralysis and permanent disability – a clinical outlook that adds urgency to vaccine development efforts. Scientists are of two minds about why these new maladies have come into view. The first is that, as the virus is spreading through such large populations, it is revealing aspects of Zika that went unnoticed in earlier outbreaks in remote and sparsely populated areas. The second is that the newly detected disorders are more evidence that the virus has evolved. “What we’re seeing are the consequences of this virus turning from the African strain to a pandemic strain,” said Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine. The suspicion that Zika acts directly on nerve cells began with autopsies on aborted and stillborn fetuses showing the virus replicating in brain tissues. In addition to microcephaly, researchers reported finding other abnormalities linked with Zika including fetal deaths, placental insufficiency, fetal growth retardation and injury to the central nervous system. Doctors also are worried that Zika exposure in utero may have hidden effects, such as behavioral problems or learning disabilities, that are not apparent at birth. “If you have a virus that is toxic enough to produce microcephaly in someone, you could be sure that it will produce a whole series of conditions that we haven’t even begun to understand,” said Dr. Alberto de la Vega, an obstetrician at San Juan’s University Hospital in Puerto Rico. A rare and poorly understood condition, Guillain-Barre can weaken muscles and cause temporary paralysis, often requiring patients to need respirators to breathe. Guillain-Barre is an autoimmune disorder, in which the body attacks itself in the aftermath of an infection. The newly discovered brain and spinal cord infections are known to be caused by a different mechanism – a direct attack on nerve cells. That has prompted scientists to consider whether the Zika virus also may infect nerves directly in adults, as they already have suspected in fetuses In medical journals published last month, doctors described neurological syndromes in two patients that they attributed to Zika. Doctors in Paris diagnosed meningoencephalitis, an infection of both the brain and spinal cord, in an 81-year-old man who was hospitalized after being exposed to Zika on a cruise. Another French team reported acute myelitis, a paralyzing infection of the spinal cord, in a 15-year-old girl who had been infected with Zika on the French Caribbean island of Guadeloupe. In its latest surveillance report, the WHO said the two cases “highlight the need to better understand the range of neurological disorders associated with Zika-virus infection.” Other mosquito-borne viruses – including dengue, Japanese encephalitis and West Nile – are known to directly infect nerve cells in the brain and spinal cord. But such viruses are seldom associated with Guillain-Barre, and never with microcephaly, said Baylor’s Hotez. Read more at http://newsdaily.com/2016/04/zika-mystery-deepens-with-evidence-of-nerve-cell-infections/#Y57C3WqytSrm3AEj.99

Vietnam reports first Zika infections.

Mosquitoes have infected two women with the Zika virus in Vietnam, health authorities said on Tuesday, in the country’s first cases of a disease linked in Brazil to thousands of suspected cases of microcephaly, a rare birth defect. A 64-year-old woman in the beach city of Nha Trang and a pregnant 33-year-old in Ho Chi Minh City fell sick in late March, and three rounds of tests have confirmed they are Zika-positive, health officials said. The sufferers are in stable condition and no further infections have been found among their relatives and neighbors, the health ministry said in a statement.“After epidemic investigations, we consider the source of infection could be mosquito,” Deputy Health Minister Nguyen Thanh Long said of the patient in Ho Chi Minh City. She is eight weeks pregnant, Long said in a Vietnam Television broadcast, but gave no details of the first woman. Health officials have quarantined the living areas of the patient’s families and taken samples from others living nearby for further tests, said Nguyen Chi Dung, head of Ho Chi Minh City’s department of preventive medicine. The World Health Organization is working closely with Vietnam, a WHO official told a health ministry meeting to announce the infections. Zika is carried by mosquitoes, which transmit the virus to humans. The WHO says there is a strong scientific consensus that Zika can cause microcephaly as well as Guillain-Barre syndrome, a rare neurological disorder that can result in paralysis, though conclusive proof may take months or years. Microcephaly is characterized by unusually small heads that can result in developmental problems. Zika has been endemic in Asia, with infection cases confirmed in Bangladesh, South Korea, Thailand and China. Brazil said it had confirmed more than 860 cases of microcephaly, most of which it considers to be related to Zika infections in the mothers. It is investigating more than 4,200 additional suspected cases of microcephaly. Read more at http://newsdaily.com/2016/04/two-vietnamese-women-contract-zika-virus-first-in-vietnam-government/#QYRfc6AIXf2ehxoY.99

PREVENTION OF SEXUAL TRANSMISSION OF ZIKA VIRUS.

Men who have traveled to an area with ongoing Zika virus transmission should consider abstaining from having sex with their pregnant partners or should “consistently and correctly use condoms” for the duration of the pregnancy, researchers cautioned. The recommendations came days after the CDC confirmed the virus had been spread through sexual contact.In two separate reports, the CDC published interim guidelines for the prevention of sexual transmission of Zika and updated interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible exposure to the primarily mosquito-borne virus. The linkage between Zika and microcephaly is stronger with each passing day, In addition, the linkage between Zika and Guillain-Barré syndrome also appears stronger the more we learn because it’s new and can be so severe, it’s scary, especially for women who are pregnant or considering pregnancy. The CDC continues to urge the use of condoms and safe sex practices to protect against the virus.Men with pregnant sexual partners who are living in areas where Zika is active or who have traveled to those places should either abstain from sexual activity or correctly use condoms during all oral, anal and vaginal sex, according to the recommendations. Men who are living in or have recently traveled to an active Zika area who are concerned about transmitting the disease to their non-pregnant partners also should consider the same precautions. The couples considering sex should take into account that most Zika infections do not have symptoms and any illness is usually mild. The CDC noted that Zika might persist in semen even after it is no longer detectable in blood. Zika testing in men is recommended to establish diagnosis of infection in groups including pregnant women. However, testing for men for the purposes of assessing their risk for sexual transmission is not recommended. Serologic testing is recommended within 2 to 12 weeks for pregnant women without symptoms who have returned from traveling to areas with ongoing Zika transmission. Testing is recommended within the first week for pregnant women with clinical illness consistent with Zika. story source;Helio infectious disease news.

ZIKA VIRUS INFECTION AND SEX.

A rare case of the Zika virus being transmitted through sex, not a mosquito bite, has been reported in the US.A patient infected in Dallas, Texas, is likely to have been infected by sexual contact, the Centers for Disease Control (CDC) told the BBC The person had not travelled to infected areas but their partner had returned from Venezuela. Zika is carried by mosquitoes and has been linked to thousands of babies being born with underdeveloped brains. It is spreading through the Americas and the World Health Organization (WHO) has declared the disease linked to the virus a global public health emergency. The American Red Cross has meanwhile urged prospective blood donors returning from Zika-hit countries to wait at least 28 days before donating their blood. The "self-deferral" should apply to people returning from Mexico, the Caribbean or Central or South America during the past four weeks, the Red Cross said in a statement. If Zika can readily spread through sex, then it poses a risk to every country not just those with the Aedes mosquito. The authorities have said sexual transmission is rare, but last year they would have said any case of Zika was rare, too. This explosive outbreak has caught the world by surprise and many key questions remain unanswered. Exactly how common or rare is sexual transmission? Can it be spread by the 80% of people who show no symptoms? How long does the virus persist in semen? When is it safe to have sex again? What should men do after visiting affected countries? Can women also spread the virus through sex? However, this is not a new HIV/Aids moment. HIV infection is incurable and dramatically shortens lives without daily medication. Zika infections are short, mild and pose a significant threat only in pregnancy. Anne Schuchat, principal deputy director for CDC, said this was the first case it had dealt with involving a "non-traveller"."We don't believe this was spread through mosquito bites, but we do believe it was spread through a sexual contact."A statement issued by the CDC said the best way to avoid Zika virus infection was "to prevent mosquito bites and to avoid exposure to semen from someone who has been exposed to Zika".The case is "significant" if it was definitely transmitted through sexual contact, Alaka Basu, a senior fellow for public health at the UN Foundation. Story credit BBC.

ZIKA VIRUS # PREGNANT WOMEN AND UNBORN BABIES.

Birth deformity linked to zika virus,thus pregnant women are advised to stay away from zones with outbreaks and those returning from such areas are advised to hold on before making babies.The adaptability of the Aedes aegypti to urban life coupled with global travelling make it a global threat. Be protected,use environmentally friendly insecticides and screened nets. Photo credit; C.D.C.

THE ZIKA THREAT.

The Zika virus,transmitted by the bite of Aedes aegypti. The mosquito vectors breed in domestic water holding containers,living in urban areas and are aggressive day-time feeders,though they feed at any time.The virus can affect any age group but pregnant women are so vulnerable with dire consequences in their babies. The virus stays 2-7 days in the blood of an infected person,thus infected people should be protected from further mosquito bites to prevent spread to more people.The basic methods to prevent infection is to prevent mosquito bites.The Aedes aegypti is also responsible for yellow fever,has been known to adapt to cold climate thus the widespread nature of the infection. The Zika virus outbreak in Latin America could be a bigger threat to global health than the Ebola epidemic that killed more than 11,000 people in Africa, claims several senior health experts ahead of an emergency meeting of the World Health Organisation. Where they will decide whether the Zika threat – which is linked to an alarming rise in cases of foetal deformation called microcephaly – should be rated a global health crisis. Jeremy Farrar, head of the Wellcome Trust, said “In many ways the Zika outbreak is worse than the Ebola epidemic of 2014-15,” “Most virus carriers are symptom less and It is a silent infection in a group of highly vulnerable individuals ( pregnant women) – that is associated with a horrible outcome for their babies.” There is no prospect of a vaccine for Zika at present, in contrast to Ebola, for which several are now under trial. “The real problem is that trying to develop a vaccine that would have to be tested on pregnant women is a practical and ethical nightmare,” added Mike Turner, head of infection and immuno-biology at the Wellcome Trust. At least 80% of those infected show no symptoms ,making tracking the disease extremely difficult. The mosquito species that spreads Zika, Aedes aegypti, has been expanding its range over the past few decades. “It loves urban life and has spread across the entire tropical belt of the planet, and of course that belt is expanding as global warming takes effect,” added Farrar. The Zika threat, can be contained with the use of insecticides to eradicate Aedes aegypti , mosquito nets and bedding's and clearing environment of stagnant water.

THE ZIKA VIRUS# MICROCEPHALY.

The Zika virus is "spreading explosively" in the Americas and the region may see up to four million cases of the disease strongly suspected of causing birth defects, the World Health Organization . The Zika virus, unlike other mosquito-borne viruses such as dengue, is relatively unknown and unstudied. That is set to change since Zika, now spreading through Latin America and the Caribbean, has been associated with an alarming rise in babies born in Brazil with abnormally small heads and brain defects -- a condition called microcephaly. Since the Zika outbreak began in northeastern Brazil last spring, an estimated 500,000 to 1.5 million people have been infected. The resulting illness only lasts a few days. The symptoms, including a rash, joint pains, inflammation of the eyes and fever, tend to be less debilitating than those of dengue. As many as 80 percent of infected people may be asymptomatic. It was not until months after Zika cases showed up in Brazil that a spike in microcephaly births was tied to women infected during pregnancy. More than 3,500 microcephaly cases have been reported since October in Brazil, compared to around 150 cases in 2014. While Zika's connection to microcephaly has yet to be definitively proven, the presence of the virus has been found in the bodies of five of the newborns that died with the condition and in the placentas of two women who miscarried babies with microcephaly.

THE ZIKA VIRUS.

On Monday (Jan. 25), the World Health Organization announced that Zika virus, a mosquito-borne illness that in the past year has swept quickly throughout equatorial countries, is expected to spread across the Americas and into the United States. Zika virus is transmitted by the mosquito species Aedes aegypti, also a carrier of dengue fever and chikungunya, two other tropical diseases. Though Aedes aegypti is not native to North America, researchers at the University of Notre Dame who study the species have reported a discovery of a population of the mosquitoes in a Capitol Hill neighborhood in Washington, D.C. , the team identified genetic evidence that these mosquitoes have overwintered for at least the past four years, meaning they are adapting for persistence in a northern climate well out of their normal range. This mosquito is typically restricted to tropical and subtropical regions of the world and not found farther north in the United States than Alabama, Mississippi, Georgia and South Carolina. What this means for the scientific world," said Severson, who led the team, "is some mosquito species are finding ways to survive in normally restrictive environments by taking advantage of underground refugia. Therefore, a real potential exists for active transmission of mosquito-borne tropical diseases in popular places like the National Mall.(source ;science daily) The emergence of mosquitoes in normally restricted areas has exposed the pandemic potential of the ZIKA VIRUS,with pregnant women at highest risk.Prevention of mosquito bites through use of treated nets,insecticides,and clearing environment of stagnant water,destruction of developmental stages and more recently the introduction of genetically modified mosquitoes to wipe out the infective strains have all been employed to reduce disease incidence. Travelling to zika-risk zones by pregnant women has also been initiated as they are mostly prone to the infection.