Universal testing contains COVID-19 outbreak in nursing home..

A nursing home in Pennsylvania rapidly contained a COVID-19 outbreak by implementing a universal testing strategy for all residents and staff, according to study findings published in Clinical Infectious Diseases.


 “We chose to publish our experience managing a COVID-19 outbreak that occurred in a local nursing home because we think that our experience in controlling the outbreak could potentially help others that work in nursing homes or long-term care facilities if they are trying to develop action plans for managing a COVID-19 outbreak in their respective facilities,” Daniel J. Escobar, MD, an infectious diseases fellow at the University of Pennsylvania, told Healio.




 According to Escobar, recently published data showed there have been more than 142,000 COVID-19 cases in nursing homes across the United States, and more than 38,000 COVID-19-related deaths. He said having a plan for management of COVID-19 outbreaks in long-term care facilities or nursing homes is essential to protect an older and more fragile population.

How thousands of gamers are helping to decode the human body.

EVE Online isn't just a game about internet spaceships and sci-fi politics. Since March, developer CCP Games has been running Project Discovery – an initiative to help improve scientific understanding of the human body at the tiniest levels. Run in conjunction with the Human Protein Atlas and Massively Multiplayer Online Science, the project taps into EVE Online's greatest resource – its player base – to help categorize millions of proteins. "We show them an image, and they can change the color of it, putting green or red dyes on it to help them analyse it a little bit better," Linzi Campbell, game designer on Project Discovery, tells WIRED. "Then we also show them examples – cytoplasm is their favourite one! We show them what each of the different images should look like, and just get them to pick a few that they identify within the image. The identifications are scrambled each time, so it's not as simple as going 'ok, every time I just pick the one on the right' – they have to really think about it." The analysis project is worked into EVE Online as a minigame, and works within the context of the game's lore. "We have this NPC organisation called the Drifters – they're like a mysterious entity in New Eden [EVE's interplanetary setting]," Campbell explains. "The players don't know an awful lot about the Drifters at the minute, so we disguised it within the universe as Drifter DNA that they were analysing. I think it just fit perfectly. We branded this as [research being done by] the Sisters of Eve, and they're analyzing this Drifter DNA." The response has been tremendous. "We've had an amazing number of classifications, way over our greatest expectations," says Emma Lundberg, associate professor at the Human Protein Atlas. "Right now, after six weeks, we've had almost eight million classifications, and the players spent 16.2 million minutes playing the minigame. When we did the math, that translated – in Swedish measures – to 163 working years. It's crazy." "We had a little guess, internally. We said if we get 40,000+ classifications a day, we're happy. If we get 100,000 per day, then we're amazed," Lundberg adds. "But when it peaked in the beginning, we had 900,000 classifications in one day. Now it's stabilised, but we're still getting around 200,000 a day, so everyone is mind-blown. We never expected it." Currently, EVE players are going through images from Lundberg's domain, who serves as director for the sub-cellular chapter of the atlas. It took players just three weeks to get through the entire workload, and are now engaging in a second pass for veracity, with no signs of interest dropping. "Part of the problem with the gamification of science is that participation rapidly drops and that's what we hoped we could prevent by doing it in an existing game, with rewards," says Lundberg. "I think that's the biggest difference, that it's integrated into the game." The Human Protein Atlas itself is expanding on the mapping of the human genome, but at a much smaller level. "We have about 20,000 genes and right now we haven't even proven that more than 70 per cent even exist. So there's a big gap between protein research and DNA research, and there are several reasons for that," says Lundberg. "DNA you can amplify so it's easy to study, but you can't amplify proteins. Also, as all cells have the same DNA, you can [just] take a blood sample [to look at]. But proteins, that's the genes that are expressed, vary through the body. You have to cover the whole body and so it's a lot more difficult, from a technological point of view, to study proteins," she continues. "From my point of view, that's the interesting part – proteins are the molecules that perform the function, and drugs act by targeting proteins. So if you want to develop better drugs, understand how humans work, or understand biology, you have to know what the proteins are doing." Players' efforts will soon be felt in the wider scientific field too. After verifying their categorisations and analyses – a process involving control images that researchers know are correct, used to measure performance of the EVE hivemind – their findings are incorporated into the HPA's database. All data is publicly available, and the atlas has around 100,000 monthly users. Already, an average of two peer-reviewed scientific papers are published every day, and when the next version of the atlas is published in December, future papers will incorporate the EVE players' data. culled from wired.co.uk