EBOLA VACCINE.

A study represents a crucial step in the translation of herpes virus-based Ebola virus vaccines into humans and other great apes. It shows the effectiveness of a herpes virus CMV-based vaccine against Ebola. Researchers have shown the ability of a vaccine vector based on a common herpes virus called cytomegalovirus (CMV) expressing Ebola virus glycoprotein (GP), to provide protection against Ebola virus in the experimental rhesus macaque, non-human primate (NHP) model. Demonstration of protection in the NHP model is regarded as a critical step before translation of Ebola virus vaccines into humans and other great apes. Establishing the potential for CMV-based vaccines against Ebola virus, these results are exciting from the potential insight they give into the mechanism of protection. Herpesvirus-based vaccines can theoretically be made to produce their targeted protein (in this case, Ebola virus GP) at different times following vaccination. The current CMV vaccine was designed to make the Ebola virus GP at later times. This resulted in the surprising production of high levels of antibodies against Ebola virus with no detectable Ebola-specific T cells. This immunological shift towards antibodies has never been seen before for such primate herpesvirus-based vaccines, where responses are always associated with large T cell responses and poor to no antibodies. The current study is a step forward, not only for conventional Ebola virus vaccines for use in humans, but also in the development of such 'self-disseminating vaccines' to target Ebola in great apes, and other emerging infectious diseases in their wild animal host before they fully establish themselves in humans. Papers from University of Plymouth.